Fischer rat thyroid
WebApr 22, 2024 · The Fischer rat thyroid follicular cell line, FRTL-5, endogenously expresses the sodium iodide symporter (NIS) and has been used to identify environmental chemicals that perturb thyroid hormone homeostasis by disruption of NIS-mediated uptake of iodide. Previously, a high-throughput radioactive iodide uptake (RAIU) screening assay using … WebDec 1, 2016 · For example, Meli et al. found that Fischer rat thyroid line-5 (FRTL-5) cells had decreased sensitivity to thyroid stimulating hormone (TSH) after exposure to a hypogravity situation [15]. In contrast, FRTL-5 exposure to a 7g centrifugal force increased TSH receptor (TSHR) number and responsiveness to TSH [14]. The difference in …
Fischer rat thyroid
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WebOct 6, 2024 · Cystic fibrosis (CF) is the most common life-threatening autosomal recessive genetic disease among Caucasians worldwide, and is caused by mutations in a single … WebJul 18, 2013 · Here, we show that Pax8 overexpression significantly increases proliferation and colony-forming efficiency of Fischer rat thyroid line 5 epithelial cells, although it is not sufficient to...
WebFischer Rat Thyroid (FRT) cells have been used extensively for studies of cystic fibrosis transmembrane conductance regulator (CFTR) protein for more than 20 years and have been a ”workhorse” for drug discovery in … WebThis study investigated the effects of thyroid disruption of malathion in Fischer rat thyroid follicular cell line, FRTL-5. Transcriptional and translational analyses on thyroglobulin demonstrated that both mRNA and protein expression levels were significantly inhibited by …
WebIn contrast to many other thyroid-restricted genes, SLC26A4 messenger RNA (mRNA) levels are not regulated by TSH in Fisher rat thyroid cell line 5 (FRTL-5) cells (Royaux et al., 2000). It is, however, significantly upregulated by TG, the major component within the luminal space of the follicle, which forms the functional unit of the thyroid. WebRat thyroid 細胞株の説明 This thyroid cell line has been established from normal thyroid glands from 5 to 6-week-old Fischer rats. FRTL-5 is a clonal line of the continuously cultured FRTL cells derived by successive clonal isolation.
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WebFischer rat thyroid cells (FRTL) were treated with Novasoy (a soy alcohol extract containing 30% ISF) or major ISF aglycones or glycosides for 24 h. Iodide uptake was measured by a colorimetric assay. The protein level of Tg and NIS was measured by Western blotting. patagonia women\u0027s retro pile fleece marsupialWebment of the kinetics of iodide influx in Fisher rat thyroid cells expressing wild-type or G551D CFTR together with the green fluorescent protein-based halide indicator YFP-H148Q. Duplicate screenings revealed that 204 compounds did not significantly affect CFTR function. Compounds of the 7,8-benzoflavone class, which are カーフィルム施工 料金 愛媛WebJun 2, 2024 · The AOP network by Noyes et al. (Citation 2024), but are recorded as leading to rat thyroid follicular tumours as adverse outcomes, ... (Citation 2024) described an in vitro Radioactive-Iodide Uptake Inhibition Screening Assay using the Fischer rat thyroid follicular cell line (FRTL-5). カーフスキンWebAug 8, 2014 · Distinction between focal, diffuse, and cystic thyroid follicular hyperplasia is recommended and should be included as a qualifier of the diagnosis. The nature of any associated hypertrophy in follicles with … patagonia women vest saleWebThis study investigated the effects of thyroid disruption of malathion in Fischer rat thyroid follicular cell line, FRTL-5. Transcriptional and translational analyses on thyroglobulin … カープ キャンプ 日程 2022WebSep 11, 2024 · Isoflavones have shown to inhibit thyroid peroxidase which is an enzyme involved in the synthesis of T 3 and T 4 . Fischer rat thyroid cells (FRTL) when treated with soy protein and isoflavones; there was a … patagonia women\u0027s retro pile fleece vestWebFeb 3, 2009 · The FRTL-5 cell line is a stable thyroid cell line derived from the thyroid gland of the Fischer rat under defined culture conditions, which has been widely … カーブス 彩都西 求人