Cisplatin with rt

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WebMar 1, 2024 · In the weekly arm, cisplatin was administered at 40 mg/m 2 once a week for seven cycles during the RT period. Criteria for dose reduction or delay were … WebOct 27, 2024 · The efficacy of the GD regimen may facilitate wider adoption of bladder preservation as many patients have comorbidities that preclude the use of cisplatin. The daily radiation schedule is also easier for patients and treatment centres to administer than twice daily treatment which will also likely increase interest in this strategy.

Concurrent cisplatin-based chemoradiotherapy versus exclusive ...

WebFeb 11, 2024 · Cisplatin was given either at a dose of 100 mg/m 2 every 3 weeks (day 1, 22, and 43) during RT (University Hospital Basel) to a planned cumulative dose of 300 mg/m 2 or at a dose of 40 mg/m 2 (University Hospital Zurich) or 50 mg/m 2 (Cantonal Hospital Winterthur) weekly for 6 or 7 infusions (days 1, 8, 15, 22, 29, 36, and 43) to a planned … WebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II study, concurrent chemoradiotherapy with TPF achieved a clinical CR rate of 52.4%, much higher than the previously reported CR rate of 20%. 9 However, the high ... dysphagia is the medical word for indigestion

Weekly cisplatin with radiotherapy for locally advanced head and …

WebCisplatin is believed to augment the effects of radiation by inhibiting the repair of radiation-induced sublethal damage and by sensitizing hypoxic cells to radiation. 9,30 Because of … WebWeekly cisplatin with radiotherapy for locally advanced head and neck squamous cell carcinoma. Our study shows that a median cumulative dose of 200 mg/m2 … WebAug 28, 2024 · The investigators primary hypothesis is that LD weekly cisplatin 40 mg/m² is associated with reduced frequency of severe hearing loss and improved hearing-related QOL when compared to conventional HD cisplatin 100 mg/m² days 1, 22 & 43 (control arm) in LASCCHN patients treated with CRT. cset reddit

Safety and efficacy of concurrent carboplatin plus radiotherapy for ...

Novel Strategies to Effectively De-escalate Curative-Intent Therapy …

WebApr 12, 2024 · The patient was started on gemcitabine, cisplatin, and nanoparticle albumin-bound paclitaxel (nab-paclitaxel). After 3 months of chemotherapy, the patient's AFP increased to 43.8 ng/ml and her CA 19-9 increased to 21.4 U/ml. On repeat CT scan, the size of the tumor was stable, but there was suspected intraductal extension toward the … WebApr 13, 2024 · Dual pi3k/mtor inhibitor nvp-bez235 leads to a synergistic enhancement of cisplatin and radiation in both hpv-negative and -positive hnscc cell lines. ... For the combination of BKM120 and RT a clinical study with HNSCC was just completed and the respective results will be expected in the near future (NCT02113878). cset register to testWebAug 29, 2012 · Cisplatin + RT for Triple Negative Breast Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT01674842 Recruitment Status : … c# setrequestheader

"WebJan 25, 2016 · Arm A represents concurrent pemetrexed-cisplatin (Pem-Cis) and thoracic radiation therapy (TRT) followed by consolidation pemetrexed. Arm B represents concurrent etoposide-cisplatin (Eto-Cis) and TRT followed by one of three consolidation chemotherapy regimens of choice: Eto-Cis, vinorelbine-cisplatin (Vin-Cis), or paclitaxel-carboplatin … " - Cisplatin with rt

Cisplatin with rt

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin …

WebThe oral vinorelbine-cisplatin combination with concurrent RT is feasible and has a favorable risk-benefit ratio in stage IIIA/IIIB NSCLC. Oral vinorelbine and cisplatin with … WebNov 1, 2007 · All patients received pelvic external beam radiotherapy (EBRT) concurrently with weekly intravenous Cis-platinum chemotherapy (40 mg/m (2)) followed by brachytherapy (BT). The median dose of EBRT was 4500 cGy …

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WebMay 27, 2024 · However, when cetuximab-based chemoradiotherapy was compared with the combination of RT and cisplatin (a crosslinking cytotoxic chemotherapy), OS, PFS, and LRC were significantly worse in unselected patients with HPV-positive oropharyngeal cancer who received cetuximab rather than cisplatin ( 4, 5 ). WebSep 29, 2015 · High-dose cisplatin (CDDP)-based chemoradiotherapy (CRT) has significantly improved overall survival (OS), progression-free survival (PFS) and locoregional control compared with that observed with radiotherapy (RT) alone in patients with locally advanced squamous cell carcinoma of the head and neck (LASCCHN) ( 1 ).

WebCisplatin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer. It may also be used to treat other cancers. It is best to read this … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …

WebFeb 2, 2024 · The benefit of adding concomitant high-dose cisplatin to adjuvant radiotherapy (RT) for resected head and neck squamous cell carcinoma (HNSCC) was … WebJan 17, 2024 · Cisplatin/Etoposide (Category 1 with RT) 2-5,a. Days 1-3: Cisplatin 25mg/m 2 IV over 60 minutes daily. Days 1-3: Etoposide 100mg/m 2 IV over 60 minutes daily. …

WebThe beneficial effects of cisplatin, which is the most widely used agent for CCRT in CC patients, whether alone or in combination with other drugs, were not independently …

WebThe beneficial effects of cisplatin, which is the most widely used agent for CCRT in CC patients, whether alone or in combination with other drugs, were not independently reported in the CCCMAC study. 37 Our study focused on the comparisons between DDP-CCRT and exclusive RT to form a definitive conclusion for this issue. Moreover, only patients ... cset review booksWebMar 23, 2012 · The study showed that tri-weekly cisplatin 75 mg/m2 concurrent to RT is feasible and increase 5-year survival rate significantly compared to weekly cisplatin 40 mg/m2 in patients with locally advanced cervical cancer (66.5% in the weekly arm, 88.7% in the tri-weekly arm; HR=0.375, 95% CI: 0.154-0.914, p= .03). dysphagia level 2 diet handoutWebJun 29, 2011 · Cisplatin is the most common agent used in combination with RT, and is one of the best studied. The standard regimen is three-weekly high-dose (100 mg/m 2) cisplatin (three cycles) concurrent with RT ( 2, 3 ). However, cisplatin at a dose of 100 mg/m 2 with concomitant RT is associated with significant acute and late toxicities ( 2, 4, … dysphagia level 2 snacksWebApr 4, 2024 · First-line Combination Therapy for Recurrent, Unresectable, or Metastatic Disease (With No Surgery or RT Option) 1 Cisplatin or carboplatin + 5-FU + cetuximab … dysphagia mechanical diet pdfWebDec 13, 2016 · This outcome is to confirm the safety and tolerability of escalating doses of BMX-001 in conjunction with RT and concurrent cisplatin in a cohort of newly diagnosed patients with locally advanced head and neck cancers. Each dose will be reported separately. Incidence Radiation-induced Mucositis by Clinician Scoring [ Time Frame: 6 … dysphagia level 3 advanced textureWebCisplatin + Fluorouracil 4-6,a,b Day 1: Cisplatin 50-75mg/m 2 IV over 60 minutes b Days 1-4: Fluorouracil 1000mg/m 2 IV continuous infusion over 24 hours daily. Repeat cycle every 3 week for 3-4 ... dysphagia is a difficulty in doing whatWebFeb 16, 2016 · Cisplatin is standardly dosed in a three-weekly schedule of 100 mg/m 2 (total dose 300 mg/m 2) combined with standard RT [3,6,7,9,10]. However, a high-dose cisplatin regimen is associated with major toxic side effects (myelosuppression, neurotoxicity, ototoxicity, and nephrotoxicity). dysphagia is defined as