Cisplatin hela

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August undefined, 2024

WebApr 29, 2015 · Hypopharyngeal squamous cell carcinoma (HSCC) has the worst prognosis among head and neck cancers. Cisplatin (DDP)-based chemotherapy is an important part of multimodal treatments. However, resistance to DDP severely impairs the effectiveness of chemotherapy for HSCC. WebMay 15, 2008 · Summary. To study the apoptosis induced by cisplatin in cervical cancer cell line HeLa and its mechanism, cell growth inhibition of cisplatin on HeLa cells …

Chloroquine-enhanced efficacy of cisplatin in the treatment of

WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … WebResults: HeLa and SiHa cells were more sensitive to cisplatin and oxaliplatin treatment than C33A cells. HeLa and SiHa cells had significantly lower NRF2 gene levels, NQO1 … slow mo consumer cameras

Transcriptome analysis of cervical cancer exosomes and detection …

WebSep 10, 2010 · Cisplatin has been widely accepted as one of the most efficient anticancer drugs for decades. However, the mechanisms for the cytotoxic effects of cisplatin are still not fully understood. Cisplatin primarily targets DNA, resulting in the formation of DNA double strand breaks and eventually causing cell death. WebFeb 10, 2024 · Cisplatin is one of the most effective chemotherapy drugs and is widely used in the treatment of cancer, including hepatocellular carcinoma (HCC) and … WebMay 26, 2011 · The cisplatin resistant cell line HeLa/CDDP was generated previously under exposure to a clinically relevant concentration of cisplatin (1 µM) and was found to … slow mo coke

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WebJul 22, 2024 · In contrast, artesunate preferably accumulates in lysosomes, activates lysosome function, and promotes ferritin degradation and free ferrous (Fe 2+) release in HeLa cervical cancer cells . This artesunate-mediated effect on the lysosome and cellular iron accumulation may also occur in HCC cells, and artesunate may further synergize … WebA cisplatin-resistant cell subline, HeLa/CDDP cells, showed a 19-fold resistance to cisplatin compared with the parent cells. The subline showed a collateral sensitivity to paclitaxel. An equitoxic dose (IC50) of cisplatin produced DNA fragmentation in HeLa … slow mode camera appWebAug 6, 2024 · Cisplatin is a platinum-based chemotherapeutic agent that is widely used for the treatment of malignant tumors, such as cervical cancer, lung cancer, and ovarian cancer [3]. Cisplatin mainly induces cross-linking at the N7-position of guanosine, which modifies DNA to induce apoptosis and kill cancer cells [4]. software server pulsa terbaik

"WebApr 21, 2024 · Cisplatin, as a significant chemotherapeutic drug for the treatment of cancers, was combined with rapamycin (RAPA), an autophagy inducer, or 3 … " - Cisplatin hela

Cisplatin hela

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WebFeb 12, 2024 · MBNL1 regulates resistance of HeLa cells to cisplatin via Nrf2 Chemotherapy is an important method in the treatment of cervical cancer, but some patients will face drug resistance, which often indicates a poor prognosis. Moreover, there is no complete solution at present. WebSep 18, 2024 · National Center for Biotechnology Information

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WebCisplatin (DDP) is one of the major chemotherapeutic drugs for cervical cancer patients. But, drug resistance limits the effectiveness of cancer therapy. Nucleolin (NCL) is a … WebNov 29, 2024 · Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment

WebCisplatin combination drugs induce stronger effects on autophagy than either of the components does. Combination drug-induced autophagy inhibits the growth of HeLa cell in a dose-dependent manner and … WebFeb 1, 2015 · In cell proliferation experiments, HeLa cells were treated with either cisplatin or myricetin and methyl eugenol alone, or vehiclealone for 12, 24 and 48 h. For apoptosis assay, cells weretreated with cisplatin or myricetin and methyl eugenol either alone or combined, or vehicle alone for 48 h.

WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … WebAug 21, 2024 · Monitoring of the HeLa and HeLa-SypHer2 tumor growth during the 35 days after tumor challenge showed that cisplatin treatment (5 mg/kg, totaling 11 doses over 4 weeks) clearly impeded tumor growth.

WebMixed lineage leukemia 5 (MLL5) transactivates the expression of E6 and E7 oncogenes in cervical cancer cells. In this study, we utilized CRISPR/Cas9 system with the aim to … software service agreement contractWebCisplatin is a platinum chemotherapeutic used in a variety of malignancies. The antineoplastic activity occurs from DNA cross-links and adducts, in addition to the generation of superoxide radicals. Nephrotoxicity is the most well-known and potentially most clinically significant toxicity. software serverWebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … software service contracts capitalizedWebIn order to assist in optimizing treatment, we applied 5-ALA/PDT in combination with low-dose cisplatin to evaluate cytotoxicity in Hela cells. Methods: Antiproliferative effects of 5-ALA/PDT and cisplatin, alone and in combination, were assessed using MTT assay. software service agreement exampleWebDrug: Cisplatin - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Genomics of Drug Sensitivity in Cancer Compound: Cisplatin Drug Target: DNA crosslinker Drug Target … slowmode command discord.pyWebJan 20, 2024 · Further investigation revealed that cisplatin-resistant cells sustain OXPHOS partly via iron metabolism reprogramming during glutamine deprivation. This reprogramming might be responsible for mitochondrial iron-sulfur [Fe-S] cluster biogenesis, which has become an "Achilles' heel," rendering cancer cells vulnerable to DFO-induced autophagic ... software service hsn codeWebWestern Blots showed that cisplatin decreased protein expression of E6 and increased protein expression of P53, p21 and Bax but had no effect on protein expression of … slowmode command discord.js