Cisplatin apoptosis induction concentration
WebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts … WebJul 1, 1999 · Treatment of each cell line with IC 90 concentrations of cisplatin yielded clear cleavage of procaspase-3 in the CP70 and C30 cells, whereas we were still unable to …
Cisplatin apoptosis induction concentration
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WebJul 3, 2024 · A single injected dose of cisplatin has been commonly used in that it is effective and practical at concentrations ranging from 10 to 30 mg/kg, as shown in Table 1. However, this approach is not similar to clinical chemotherapy in which cisplatin is administered as a single intravenous dose every 4 to 6 weeks with as many as six … WebJan 1, 2007 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis …
WebMar 1, 2006 · The chloride ions in cisplatin are particularly important in its action as a drug. They are relatively stable when the drug is outside the cell, where the chloride concentration is normally high. But when the drug gets inside the cell and the chloride concentration drops, cisplatin loses its two chlorides, and they are replaced by water … WebJan 18, 2016 · Cisplatin induces apoptosis in renal tubular cells. (A and B) NRK-52E cells treated with or without (Ctrl) different concentrations of cisplatin (10–50 μmol/L) for 24 h were subjected to phase ...
WebWe previously described that blocking ALDH activity enhances the induction of apoptosis, especially in ovarian cancer stem cells treated with chemotherapeutic agents. ... According to Table 1, the combination of cisplatin at the concentration of 0.4 µM, which is a reduction by 51.06-fold from 22 µM, with paclitaxel at 0.03 µM, ... WebApr 28, 2011 · Cisplatin is a chemotherapeutic drug widely used in the treatment of a variety of cancers, including sarcomas, lymphomas, and some carcinomas such as small …
WebThe anticancer drug cisplatin induces cell death by apoptosis. Apoptosis is dependent on cellular loss of potassium ions (K+). We have recently shown that the antifungal drug amphotericin B (enhancin
WebApr 28, 2011 · For all cell lines, it is true that concentrations of cisplatin up to 30μM caused mainly a mode of cell death with clear morphological and biochemical characteristics of apoptosis, whereas the commonest phenotype observed with concentrations equal or higher than 300μM had clearly lost many of these characteristics and more closely … green row portseaWebWe have treated four prostate tumor cell lines, DU-145, PC-3, LNCaP and 22RV1 with various concentrations of cisplatin in order to check for influence on viability and for onset of apoptosis induction. At a cisplatin concentration of 20 microM, 22RV1 and DU-145 cells showed approximately 22% and 18% and PC-3 and LNCaP cells showed … fly with sasWebMar 9, 2024 · The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, apoptosis, oxidative stress, inflammation, and vascular injury in the kidneys. At present, there are no effective drugs or methods for cisplatin-induced kidney injury. fly with robert spinks airportWebIn contrast, in the spheroids treated with cisplatin (33 μM) an evident increase in the activity of these caspases is observed up to 1500 RLUs, indicating induction of apoptosis. To confirm the lack of apoptosis activation, the activity of initiator caspases 8 and 9 was measured through the effect of specific inhibitors on cell viability of ... fly with robertWebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... adenocarcinoma promotes proliferation via the accumulation of β-catenin 17 and regulates lung tumorigenesis through cell apoptosis and autophagy pathways. 16 USP14 is critical ... fly with regular drivers licenseWebA high concentration of cisplatin induces apoptosis in many tumor cell lines. Whether cisplatin induces apoptosis even in a controlled release formulation has not been … fly with ptiWebCisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent. However, it remains as one of the most widel 掌桥科研 一站式科研服务平台 fly with ryanair